Providing reliable and high data rate wireless transmission to indoor users is very challenging because the metallic structure of a building can reflect and block signals from getting to the users. The most feasible way to improve the wireless system performance is to get the transmitter and receiver closer to each other. In-building distributed antenna systems (DASs) using radio-over-fiber (RoF) technology can be used to provide improvement in wireless system capacity and coverage. However, the implementation of current wireless multi-antenna technology in an in-building DASs presents great challenges. My research experimentally investigates the technical issues with MIMO over RoF-DAS, and algorithms for implementing multi-antenna schemes in a microwave and millimeter-wave RoF-based DASs to improve wireless access rates.